منابع مشابه
hbsag variants: common escape issues
abstract mutations have been described in all of the four open reading frames of the hepatitis b virus (hbv), however, from a clinical perspective the surface escape mutant is the most troublesome. hepatitis b surface antigen (hbsag) variants may impair diagnosis, or allow the virus to escape vaccine-induced immunity or passive immunoglobulin therapy. hbv mutants with amino acid substitutions, ...
متن کاملConstruction and Expression of Hepatitis B Surface Antigen Escape Variants within the "a" Determinant by Site Directed Mutagenesis
Background: The antibody response to hepatitis B surface antigen (HBsAg) controls hepatitis B virus infection. The "a" determinant of HBsAg is the most important target for protective antibody response, diagnosis and immunoprophylaxis. Mutations in this area may induce immune escape mutants and affect the performance of HBsAg assays. Objectives: To construct clinically relevant recombinant muta...
متن کاملIssues in Process Variants Mining
In today’s dynamic business world economic success of an enterprise increasingly depends on its ability to react to internal and external changes in a quick and flexible way. In response to this need, processaware information systems (PAIS) emerged, which support the modeling, orchestration and monitoring of business processes and services respectively. Recently, a new generation of flexible PA...
متن کاملCommon Bayesian models for common cognitive issues.
How can an incomplete and uncertain model of the environment be used to perceive, infer, decide and act efficiently? This is the challenge that both living and artificial cognitive systems have to face. Symbolic logic is, by its nature, unable to deal with this question. The subjectivist approach to probability is an extension to logic that is designed specifically to face this challenge. In th...
متن کاملCytotoxic T lymphocyte responses and CTL epitope escape mutation in HBsAg, anti-HBe positive individuals.
BACKGROUND/AIMS Clearance of hepatitis B virus (HBV) is characterised by a strong cytotoxic T cell response. Persistence of HBV in chronic hepatitis B carriers may be related to failure of this response. The aim of this study was to determine whether HLA class I restricted cytotoxic T lymphocyte (CTL) responses persist in anti-hepatitis B e (HBe) positive / HBV DNA negative individuals, and to ...
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ژورنال
عنوان ژورنال: Jundishapur Journal of Microbiology
سال: 2012
ISSN: 2008-3645,2008-4161
DOI: 10.5812/jjm.4243